Feeding the microbiota–gut–brain axis: Nucleotides and their role in early life

Nucleotides ingested from breast milk and complementary foods during infancy play a vital role in the development of immune nervous system, as well maturation gut function, are considered “special dietary nutrient.” Based on existing research progress theoretical basis, this review takes distribution nucleotides (NTs) early life (after birth to age 3 years) diet vivo metabolism/absorption process starting point expounds its potential impact mechanism action gastrointestinal brain development. With understanding microbiota (GM), interaction between factors GM has become focus food research. It is great significance reexamine biological effects nucleotide intake infant gut–brain perspective GM–gut–brain axis. This paper reveals relationship NTs–GM–gut–brain axis provides new ideas theories for application NTs field nutrition.